The site by the ICP (Interactive Clinical Pharmacology) of New Zealand has been designed to increase understanding of important concepts and principles in Clinical Pharmacology. it gives us an insight on how drugs work and effect our body. Examples on the site have been developed using Macromedia Flash to enable user interaction.
Here are the 16 interesting topics covered.
- Drug Clearance
- Saturable Metabolism
- Drug Elimination
- Protein Binding
- Volume of Distribution
- pH and Pharmacokinetics
- Half Life
- Dosing and Age
- Dosing-I.V. vs oral vs slow release
- Drugs in Pregnancy
- Oral Availability
- Drug Interactions
- Drug Transport
- Graph Plotter
You will learn what steady rate concentration means.
Learn how drug molecules interact with enzymes to form metabolites.
Learn how altered liver and kidney functions may affect drug clearance.
Only important in interpreting measured drug concentrations.
The volume into which a drug appears to be distributed. Determines loading dose.
Acids are ionized in basic media. Bases are ionized in acidic media.
The time for the concentration of the drug to halve.
Drug clearance and dose requirements vary between ages.
The route of drug administration influences pharmacokinetics.
Effect of drugs on the pregnancy and vice versa.
The fraction of drug that reaches the systemic circulation after oral ingestion.
When drug concentrations exceed the capacity of metabolism.
The action of the drug on the body.
Active transporters can help prevent some drug toxicities and aid uptake of some drugs. Check out the human model
How genes determine drug concentrations.
Varying dose regimen for different clinical settings.