Medical Science

How drugs work in our body

The site by the ICP (Interactive Clinical Pharmacology) of New Zealand has been designed to increase understanding of important concepts and principles in Clinical Pharmacology. it gives us an insight on how drugs work and effect our body. Examples on the site have been developed using Macromedia Flash to enable user interaction.

Here are the 16 interesting topics covered.

  1. Drug Clearance
  2. You will learn what steady rate concentration means.

  3. Saturable Metabolism
  4. Learn how drug molecules interact with enzymes to form metabolites.

  5. Drug Elimination
  6. Learn how altered liver and kidney functions may affect drug clearance.

  7. Protein Binding
  8. Only important in interpreting measured drug concentrations.

  9. Volume of Distribution
  10. The volume into which a drug appears to be distributed. Determines loading dose.

  11. pH and Pharmacokinetics
  12. Acids are ionized in basic media. Bases are ionized in acidic media.

  13. Half Life
  14. The time for the concentration of the drug to halve.

  15. Dosing and Age
  16. Drug clearance and dose requirements vary between ages.

  17. Dosing-I.V. vs oral vs slow release
  18. The route of drug administration influences pharmacokinetics.

  19. Drugs in Pregnancy
  20. Effect of drugs on the pregnancy and vice versa.

  21. Oral Availability
  22. The fraction of drug that reaches the systemic circulation after oral ingestion.

  23. Drug Interactions
  24. When drug concentrations exceed the capacity of metabolism.

  25. Pharmacodynamics
  26. The action of the drug on the body.

  27. Drug Transport
  28. Active transporters can help prevent some drug toxicities and aid uptake of some drugs. Check out the human model

  29. Pharmacogenetics
  30. How genes determine drug concentrations.

  31. Graph Plotter
  32. Varying dose regimen for different clinical settings.

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